Seminar of the Department of Biochemistry and Molecular Medicine
We would like to inform faculty members, students, and postdocs in the Department of Biochemistry and Molecular Medicine that Dr. Paul Schedl, full professor at Princeton University, will be giving a lecture on Wednesday, October 21, at 11:30 a.m., in the André-Barbeau Room at the Montreal Clinical Research Institute (IRCM).
Speaker: Dr. Paul Schedl
Full Professor
Department of Molecular Biology
Princeton University
Princeton, NJ, United States
Host: Nicole Francis, Ph.D.
Jour et Date : Mercredi 21 octobre
Time: 11:30 a.m. – 12:30 p.m.
Location : André-Barbeau Hall at the Montreal Clinical Research Institute (IRCM)
| Conference Summary
Studies dating back to the late 1800’s first suggested that the euchromatic regions of chromosomes in multicellular animals are organized into a series of looped domains. While there is now general agreement in the field that chromosomes are subdivided into topologically isolated loops (now called TADs), the mechanisms responsible for generating these loops are controversial. The first part of the seminar will describe how loops (TADs) are formed and how this mechanism generates loops that have distinct topologies and consequently different genetic properties. The second part of the seminar will focus on a special class of elements whose primary function is to bring distant regulatory elements (enhancers/silencers) into contact with their gene target. In the third part of the seminar, a new Hi-C procedure will be described. This procedure provides high-resolution (100 bp) images of the physical interactions within (and between) TADs. In addition to showing that enhancers come into direct (ligatable) physical contact with their target promoters, it is clear from the patterns physical interactions detected by this Hi-C procedure that (many) TADs are not simple loops, but instead have a complicated (and likely dynamic) internal organization. |
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