{"id":17080,"date":"2026-03-27T15:46:04","date_gmt":"2026-03-27T19:46:04","guid":{"rendered":"https:\/\/ci2bmontreal.ca\/?p=17080"},"modified":"2026-03-27T16:01:31","modified_gmt":"2026-03-27T20:01:31","slug":"unveiling-the-architectural-complexity-of-yeast-telomerase","status":"publish","type":"post","link":"https:\/\/ci2bmontreal.ca\/en\/unveiling-the-architectural-complexity-of-yeast-telomerase\/","title":{"rendered":"Unveiling the architectural complexity of yeast telomerase"},"content":{"rendered":"\n
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Overview<\/strong> The maintenance of chromosome ends, known as telomeres, is a fundamental process for genome stability in almost all eukaryotes. At the heart of this mechanism is telomerase, a specialized reverse transcriptase that adds telomeric repeats to counter the “end replication problem”. Although telomerase is a prime target for research into cancer and age-related disorders, our understanding of its diverse structural forms across species remained incomplete. <\/p>\n

A new study published by researchers at the MRC Laboratory of Molecular Biology (LMB), Universit\u00e9 de Sherbrooke, and Pascal Chartrand of CI2B<\/sup>, Universit\u00e9 de Montr\u00e9al, presents the first structure of the telomerase holoenzyme from budding yeast using high-resolution cryo-electron microscopy (cryo-EM), revealing a molecular architecture that diverges considerably from its human and ciliate counterparts.<\/p>\n\n

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Unlocking the secrets of telomerase with yeast<\/strong><\/h1>\n\n\n\n

A major discovery reveals the architecture of telomerase, an enzyme closely linked to aging and cancer.<\/p>\n\n\n\n

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Full article on UdeMNouvelles (French)<\/a><\/div>\n<\/div>\n<\/div><\/div>\n<\/div><\/div>\n\n
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Pascal Chartrand<\/p>\n\n\n\n

Member of the Institut Courtois d’innovation biom\u00e9dicale and senior co-author of the study<\/p>\n<\/div><\/div>\n","protected":false},"excerpt":{"rendered":"

Overview The maintenance of chromosome ends, known as telomeres, is a fundamental process for genome stability in almost all eukaryotes. At the heart of this mechanism is telomerase, a specialized […]<\/p>\n","protected":false},"author":4,"featured_media":17078,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[798],"tags":[],"class_list":["post-17080","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news"],"acf":[],"_links":{"self":[{"href":"https:\/\/ci2bmontreal.ca\/en\/wp-json\/wp\/v2\/posts\/17080","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/ci2bmontreal.ca\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/ci2bmontreal.ca\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/ci2bmontreal.ca\/en\/wp-json\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/ci2bmontreal.ca\/en\/wp-json\/wp\/v2\/comments?post=17080"}],"version-history":[{"count":2,"href":"https:\/\/ci2bmontreal.ca\/en\/wp-json\/wp\/v2\/posts\/17080\/revisions"}],"predecessor-version":[{"id":17083,"href":"https:\/\/ci2bmontreal.ca\/en\/wp-json\/wp\/v2\/posts\/17080\/revisions\/17083"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/ci2bmontreal.ca\/en\/wp-json\/wp\/v2\/media\/17078"}],"wp:attachment":[{"href":"https:\/\/ci2bmontreal.ca\/en\/wp-json\/wp\/v2\/media?parent=17080"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/ci2bmontreal.ca\/en\/wp-json\/wp\/v2\/categories?post=17080"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/ci2bmontreal.ca\/en\/wp-json\/wp\/v2\/tags?post=17080"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}